Ženske niso edine, ki občutijo posledice hormonskih sprememb, saj zdravniki opažajo, da moški pogosto poročajo o enakih simptomih, kot jih ženske doživljajo v obdobju perimenopavze in menopavze. Medicinska skupnost še vedno razpravlja o tem, ali moški dejansko prehajajo skozi natančno določeno menopavzo v času, ko se raven njihovega hormona testosterona zmanjšuje. Zanimivo pa je, da moški, ki prejemajo hormonsko terapijo s testosteronom, občutijo olajšanje simptomov, povezanih s to tako imenovano moško menopavzo.
Ker moški ne gredo skozi jasno opredeljeno obdobje, ki bi ga lahko neposredno primerjali z žensko menopavzo, se zdravniki s to težavo soočajo prek upada koncentracije androgenih hormonov pri starejših moških. S staranjem je upad nastajanja testosterona povsem običajen pojav, vendar se to lahko zgodi tudi zaradi določenih bolezenskih stanj, kot je na primer sladkorna bolezen. Poleg upada proizvodnje testosterona nekateri moški doživljajo simptome, kot so utrujenost, slabost, depresija in spolne težave, vendar je povezava teh simptomov z znižano ravnjo testosterona še vedno predmet razprav. Za razliko od menopavze pri ženskah, kjer se nastajanje hormonov popolnoma ustavi, je upad pri moških precej počasnejši proces. Testisi, v nasprotju z jajčniki, namreč ne izgubijo kemične snovi, ki je potrebna za nastajanje testosterona, zato so zdravi moški sposobni proizvajati spermo še v svojih osemdesetih letih ali celo dlje.
Vprašanje, ali se moška menopavza lahko zdravi, ima pritrdilen odgovor, saj lahko nadomestna terapija s testosteronom olajša simptome, če je raven tega hormona prenizka. To vključuje izboljšanje libida oziroma zanimanja za spolnost ter zmanjšanje občutkov depresije in utrujenosti. Vendar pa ima nadomestna terapija s testosteronom, podobno kot hormonska terapija pri ženskah, določena tveganja in stranske učinke. Takšno zdravljenje lahko na primer poslabša rak prostate ali poveča tveganje za srčna obolenja.
Vsak moški, ki se odloči za androgeno nadomestno terapijo, se mora najprej posvetovati z zdravnikom, ki lahko poleg zdravil priporoči tudi določene spremembe v življenjskem slogu za lajšanje simptomov. Zdravnik morda ne bo svetoval začetka terapije, če je v bližnji prihodnosti pomembna plodnost osebe, prav tako se terapija odsvetuje pri moških z zgodovino raka prostate, nezdravljeno spalno apnejo ali nekontroliranim srčnim popuščanjem. Drugi zadržki vključujejo preteklo pojavljanje krvnih strdkov v nogah ali pljučih in nedavno preživeto srčno ali možgansko kap. Če bolnik sumi, da ima nizko raven testosterona, se mora z zdravnikom pogovoriti o svojih simptomih, morebitnih testiranjih in najprimernejši obliki zdravljenja. N
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